Tipifarnib S Enantiomer No CAS: 192185-71-0
Estrikti chimik: Tipifarnib S enantiomer
Nimewo CAS: 192185-71-0
Dekri teren
Estrikti chimik: Tipifarnib S enantiomer
Nimewo CAS: 192185-71-0
Tipifarnib S enantiomer((S)-(-)-R-115777;IND-58359 S enantiomère)
Katalòg No.: URK-V592Itilize sèlman pou laboratwa.
Tipifarnib S enantiomer (IND-58359 S enantiomer) se yon inibitè ki pisan ak selektif nan FTase (farnesyltransferase).
Aktivite Byolojik
Tipifarnib S enantiomer, the S-enantiomer of Tipifarnib, is a potent and selective inhibitor of FTase (farnesyltransferase); inhibits the farnesylation of lamin B and K-RasB peptide substrates with IC50s of 0.86 nM and 7.9 nM, respectively; no activity for PGGT1(IC50>50 uM); montre sansiblite pou liy selil timè ki gen mitasyon H-ras oswa N-ras; inibit kwasans lan nan timè ki bay sourit ak oral byodisponib. Tipifarnib S enantiomer se yon izomè inaktif
Kansè san
Pwopriyete fizikochimik
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M.Wt |
489.396 |
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Fòmil |
C27H22Cl2N4O |
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Nimewo CAS |
192185-71-0 |
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Depo |
Solide poud -20 degre 3an; 4 degre 2 zan |
Nan Solvant -80 degre 6 Mwa -20 degre 1 Mwa |
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Solibilite |
10 mM nan DMSO |
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Non Chimik |
6-[(S)-amino(4-klorofenil)(1-metil-1H-imidazol-5-il)metil]-4-({ {8}}klorofenil)-1-metil-2(1H)-chinolinon |
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Referans
1. Fen DW, et al. Kansè Res. 2001 1 janvye; 61(1):131-7.
2. Kelland LR, et al. Clin Cancer Res. 2001 Novanm; 7(11):3544-50.
3. Beaupre DM, et al. Mol Kansè Ther. 2004 fevriye; 3(2):179-86.
URK-V592_COAURK-V592_SDSURK-V592_TDS
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Baj popilè: tipifarnib s enantiomer cas no.: 192185-71-0
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