Dekri teren
Estrikti chimik: BMS-986235
Nimewo CAS: 2253947-47-4
BMS-986235(LAR-1219)
Katalòg No.: URK-V2352Itilize sèlman pou laboratwa.
BMS-986235 (LAR-1219) is a potent, selective, and orally bioavailable agonist of formyl peptide receptor 2 (FPR2) with EC50 of 0.4 nM (hFPR2), >7,000-pliye selektivite sou FPR1.
Aktivite Byolojik
BMS-986235 (LAR-1219) is a potent, selective, and orally bioavailable agonist of formyl peptide receptor 2 (FPR2) with EC50 of 0.4 nM (hFPR2), >7,000-pliye selektivite sou FPR1.
BMS-986235 te pwodwi modulation depandan de konsantrasyon nan siyal BRET pou G i1, G i2, G i3, G oA, ak G oB byodetèktè apre aktivasyon FPR2 (EC50=5-13 nM), 164- pou 614-pliye selektivite sou aktivasyon FPR1.
BMS-986235 amelyore siviv sourit, redwi zòn vantrikul gòch, redwi zòn mak, ak konsève epesè miray la, anpeche chemotaxis netrofil ak ankouraje fagositoz macrophage, pwen final kle pou ankouraje rezolisyon enflamasyon.
BMS-986235 te prezève myokad solid, atenue renovasyon vantrikul gòch, ak ogmante fraksyon ekspilsyon nan rat apre MI.
FizyoteramMikal Prpwopriyete yo
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M.Wt |
361.349 |
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Fòmil |
C18H17F2N3O3 |
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Nimewo CAS |
2253947-47-4 |
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|
Depo |
Solide poud -20 degre 3an; 4 degre 2 zan |
Nan Solvant -80 degre 6 Mwa -20 degre 1 Mwa |
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Solibilite |
10 mM nan DMSO |
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Non Chimik |
1-((3S,4R)-4-(2,6-difluoro-4-metoksifenil)-2-oksopirrolidin-3-il)-3- fenilurea |
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Referans
1. Yoshikazu Asahina, et al. J Med Chem. 2020 septanm 10;63(17):9003-9019.
2. Ricardo A García, et al. JACC Basic Transl Sci. 23 out 2021;6(8):676-689.
URK-V2352_COAURK-V{{1}sdsURK-V{{1}tsRemak: Tout pwodwi Ureiko yo itilize sèlman pou rechèch syantifik oswa deklarasyon sètifika dwòg, epi nou pa bay pwodwi ak sèvis pou nenpòt itilizasyon pèsonèl!
Baj popilè: bms986235 ka nimewo:2253947-47-4
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