Dekri teren
Estrikti chimik: Tropifexor
Nimewo CAS: 1383816-29-2
Tropifexor(LJN-452;LJN452)
Katalòg No.: URK-V590Itilize sèlman pou laboratwa.
Tropifexor (LJN{{0}}, LJN452) se yon agonist FXR ki trè pisan, selektif, aktif oralman ak EC50 nan 0.20 nM.
Aktivite Byolojik
Tropifexor (LJN-452, LJN452) is a novel highly potent, selective, orally acitive FXR full agonist with EC50 of 0.20 nM; shows no significant off-target activity (>10,000-fold selectivity for FXR) in a panel of targets, including TGR5 (>10 uM); demontre aktivite in vivo nan modèl PD wonjè, epi li montre potansyèl pou tretman maladi fwa kolestatik ak NASH.
Steatoepatit
Faz 2 klinik
Pwopriyete fizikochimik
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M.Wt |
603.589 |
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Fòmil |
C29H25F4N3O5S |
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Nimewo CAS |
1383816-29-2 |
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Depo |
Solide poud -20 degre 3an; 4 degre 2 zan |
Nan Solvant -80 degre 6 Mwa -20 degre 1 Mwa |
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Solibilite |
10 mM nan DMSO |
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Non Chimik |
LJN 452;LJN-452;LJN452;CS{{3};CPD1549;Tropifexor; 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[{2-(trifluoromethoxy)phenyl]-1,{{ 9}}oksazol-4-il}metoksi)-8-azabicyclo[3.2.1]oktan-8-il]-4-fluoro-1,3-benzotiazol -6-asid karboksilik |
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Referans
1. Tully DC, et al. J Med Chem. 2017 Desanm 8. doi: 10.1021/acs.jmedchem.7b00907.
URK-V590 COAURK-V590_Fèy DoneURK-V{{1}sds
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Baj popilè: tropfexor cas no.: 1383816-29-2
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