S63845 Nimewo CAS:1799633-27-4

Estrikti chimik: S-63845

Nimewo CAS: 1799633-27-4

 

S-63845(S 63845;S63845)

Katalòg No.: URK-V734Itilize sèlman pou laboratwa.

S-63845 (S63845) is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 UM).

Aktivite Byolojik

S-63845 (S63845) is a highly potent, selective Mcl-1 inhibitor with Kd of 0.19 nM, with no appreciable binding affinity to BCL-2 or BCL-XL (Ki>10 uM); mare nan renur BH3-lye Mcl-1, li ka touye selil kansè ki depann de MCL1-, ki gen ladan myelom miltip (IC50).<0.1 uM), leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway; is well tolerated and shopws high effectivity against mouse cancer models.
Kansè san
Preklinik

Pwopriyete fizikochimik

Referans

1. Kotschy A, et al. Lanati. 27 oktòb 2016;538(7626):477-482.

2. Merino D, et al. Sci Transl Med. 2017 Out 2;9(401). pii: eaam7049.

3. Letai A. Selil Kansè. 2016 Desanm 12;30(6):834-835.

URK-V734_COA

URK-V{{1}sds

URK-V{{1}ts

 

Remak: Tout pwodwi Ureiko yo itilize sèlman pou rechèch syantifik oswa deklarasyon sètifika dwòg, epi nou pa bay pwodwi ak sèvis pou nenpòt itilizasyon pèsonèl!

Baj popilè: s63845 ka nimewo:1799633-27-4